Coronary Heart Disease Statistics in US 2026 | Key Facts

Coronary Heart Disease in US

What is Coronary Heart Disease in America 2026

Coronary heart disease (CHD) — also called coronary artery disease (CAD) — is the single most common and deadliest form of cardiovascular disease in the United States. It occurs when fatty deposits known as plaque build up inside the coronary arteries, the vessels responsible for delivering oxygen-rich blood to the heart muscle. Over time, this process — called atherosclerosis — narrows the arteries and restricts blood flow, which can trigger chest pain (angina), heart attacks (myocardial infarctions), dangerous arrhythmias, and sudden cardiac death. According to the Centers for Disease Control and Prevention (CDC), coronary heart disease has been the leading cause of death in the United States since 1921 — a grim record spanning more than 104 consecutive years. As of 2026, despite enormous progress in medicine and public health, CHD remains responsible for 38.2% of all cardiovascular deaths in the country, making it far and away the dominant killer within the already-massive burden of heart disease.

What gives coronary heart disease statistics in America 2026 particular urgency is the convergence of several deeply troubling trends happening simultaneously. The AHA 2026 Heart Disease and Stroke Statistics Update, published January 21, 2026, in Circulation, reveals that while the absolute number of CHD deaths declined slightly from 2022 to 2023 — a modest piece of good news — nearly half of all US adults now live with some form of cardiovascular disease, a rate still higher than pre-pandemic levels. At the same time, the JACC Cardiovascular Statistics 2026 report, published January 12, 2026, confirms that CAD prevalence has been climbing steadily since 2019 across nearly every demographic subgroup, while the three major upstream risk drivers — hypertension, diabetes, and obesity — are all getting worse, not better. For every American who reads this article, understanding these numbers in full is the first and most important step toward meaningful, life-saving action.

Interesting Key Facts About Coronary Heart Disease in the US 2026

Before the detailed statistics sections, here is a consolidated table of the most striking and verified facts about coronary heart disease in America, drawn exclusively from the most authoritative peer-reviewed and government sources available as of February 27, 2026.

Key FactVerified Data Point
CHD is the most common type of heart disease in the USConfirmed — CDC, cdc.gov, updated October 2024
CHD deaths in 2023 (most recent year)349,470 Americans died from coronary heart disease
CHD deaths in 2022371,506 — a decline of ~22,000 deaths year-over-year
CHD’s share of all CVD deaths in 202338.2% of all cardiovascular disease deaths
Total CVD deaths in 2023915,973 — down from 941,652 in 2022
CVD death frequency in 2023Someone died of CVD every 34 seconds
CHD death frequency in 2023About 2 people died of heart disease every 3 minutes
CAD prevalence trendDeclined 1990–2015; rising steadily since 2019
CAD prevalence among US adults age 20+ (2022)Approximately 5% (~1 in 20 adults)
Adults with any form of CVD (2021–2023)~50% of all US adults
Annual heart attacks in the USApproximately 805,000 per year
Heart attack frequencyOne every 40 seconds in the US
First heart attacks annually605,000
Recurrent heart attacks annually200,000
Silent heart attacksAbout 1 in 5 (20%) are silent
Average age of first MI — men65.6 years
Average age of first MI — women72.0 years
CHD patients receiving optimal medical therapyOnly 1 in 2 (50%) — JACC Stats 2026
CAD mortality reduction (2000–2020)Approximately ~50% decrease
CHD age-adjusted death rate change (2012–2022)Declined 16.9%
US adults with high blood pressure (2021–2023)125.9 million — 47.3% of all US adults
US adults with diagnosed diabetes (2021–2023)29.5 million diagnosed; 96 million with prediabetes
Obesity among US adults (NHANES 2021–2023)40.1% — epidemic proportions
Adults with ZERO CVD risk factorsOnly 36.4%
Total CVD cost — US (2021–2022)Estimated $414.7 billion
Heart disease as leading cause of death since1921 — over 104 years straight

Source: AHA 2026 Heart Disease and Stroke Statistics Update — Palaniappan LP et al., Circulation, January 21, 2026 (doi: 10.1161/CIR.0000000000001412); JACC Cardiovascular Statistics in the United States, 2026 — Wadhera RK et al., J Am Coll Cardiol., January 12, 2026 (doi: 10.1016/j.jacc.2025.12.027); CDC Heart Disease Facts, cdc.gov, updated October 2024; CDC NCHS Multiple Cause of Death 2023, CDC WONDER Database, accessed February 1, 2025; AHA 2026 At-a-Glance Fact Sheet, professional.heart.org, January 2026.

These facts collectively reflect a nation at a pivotal and precarious crossroads with its cardiovascular health. The slight decline in CHD deaths from 371,506 in 2022 to 349,470 in 2023 is genuinely welcome — it reflects the post-pandemic rebound in life expectancy and continued improvements in acute cardiac care. But that modest progress stands in stark contrast to a deeply troubling undercurrent: CAD prevalence has been rising since 2019, nearly half of all American adults already have some form of cardiovascular disease, and the foundational risk factors — particularly high blood pressure (47.3% of adults), diabetes (29.5 million diagnosed), and obesity (40.1%) — are all trending in the wrong direction. With only 1 in 2 CHD patients receiving optimal medical therapy and only 36.4% of adults carrying zero CVD risk factors, the prevention gap is as wide as ever. These numbers are not statistical abstractions — they represent real, preventable loss of life happening every single day across every state in the country.

Coronary Heart Disease Prevalence Statistics in the US 2026

Understanding how many Americans are currently living with coronary heart disease — and how those numbers are changing — is the essential starting point for any meaningful clinical or policy response to this epidemic.

Population GroupCAD/CHD PrevalenceTrend
All US adults age 20+ (CDC measure)Approximately 5% (~1 in 20)Rising since 2019
All US adults — any CVD (2021–2023)~50% (~127+ million adults)Up from 48.6% in 2017–2020
Men overall (2022, BRFSS/NHANES)6.4%Up from 5.9% in 2019
Women overall (2022, BRFSS/NHANES)3.6%Up from 3.4% in 2019
Adults aged 75 and older19.7%Up from 19.2% in 2019
White adults (2022)5.4% — highest of all racial groupsRising
Asian adults (2022)3.8% — lowest of all racial groupsUp sharply from 2.8%
Non-Hispanic Black adults — any CVD (2017–2020)~59% CVD prevalencePersistent, severe disparity
Veterans12.6%–13.4%Far above national average
Unemployed adults (2019–2022)9.9%–10.3%vs. only 1.7–1.9% for employed
Heart failure prevalence (2021–2023)7.7 million US adultsUp from 6.7 million in 2017–2020
Youth obesity (age 2–19, 2021–2023)28.1%Up from 25.4% — future CHD pipeline

Source: JACC Cardiovascular Statistics in the United States, 2026 — Wadhera RK et al., J Am Coll Cardiol., January 12, 2026; AHA 2026 Heart Disease and Stroke Statistics Update — Palaniappan LP et al., Circulation, January 21, 2026; CDC BRFSS 2022 dataset; CDC Heart Disease Facts, cdc.gov, October 2024.

The prevalence picture for coronary heart disease in the US 2026 is one of modest long-term progress being steadily unwound by modern lifestyle trends. The headline finding from JACC Stats 2026 is unambiguous: after two-plus decades of steady decline in CAD prevalence from 1990 through 2015, followed by a period of relative stability, rates have been climbing consistently since 2019 across almost all demographic subgroups. Men’s CAD prevalence jumped from 5.9% to 6.4% in just three years (2019–2022), while Asian adults — previously among the lowest-risk groups — saw their rate leap from 2.8% to 3.8%, a 36% relative increase that demands urgent attention and targeted outreach. The stark disparity between veterans (prevalence of 12.6%–13.4%) and non-veterans underscores the long-term cardiovascular toll of military service, while the powerful association between unemployment and CAD (rates up to 10.3% vs. only 1.9% for employed adults) confirms that cardiovascular disease cannot be understood or addressed without understanding the economic and social conditions in which it develops. With youth obesity now at 28.1% — up from 25.4% just a few years ago — the pipeline for the next generation of CHD patients is already filling.

Coronary Heart Disease Mortality Statistics in the US 2026

Mortality data — who is dying from CHD, at what rate, and whether that rate is improving — is the most direct and sobering measure of where this disease stands against all the resources society has devoted to fighting it.

Mortality MetricLatest Verified Figure
CHD deaths in 2023349,470 (underlying cause)
CHD deaths in 2022371,506
Year-over-year change (2022 to 2023)Decrease of ~22,036 deaths (-5.9%)
CHD’s share of all CVD deaths in 202338.2% — largest single CVD cause of death
Total CVD deaths in 2023915,973
Total CVD deaths in 2022941,652
Age-adjusted CVD death rate (2023)218.3 per 100,000 people
Age-adjusted CVD death rate (2022)224.3 per 100,000
CVD death frequency in 2023One death every 34 seconds
CHD death frequency in 2023About 2 people every 3 minutes
CHD age-adjusted death rate change (2012–2022)Declined 16.9%
CAD mortality reduction (2000–2020)Approximately ~50% decrease
CVD deaths among adults under 65 (2023)About 1 in 6 CVD deaths
CVD deaths vs other causesMore than cancer and accidents combined
Heart disease as leading cause of death since1921 — 104 consecutive years

Source: AHA 2026 Heart Disease and Stroke Statistics Update — Palaniappan LP et al., Circulation, January 21, 2026 (doi: 10.1161/CIR.0000000000001412); AHA 2026 At-a-Glance Fact Sheet, professional.heart.org, January 2026; CDC NCHS Multiple Cause of Death 2023, CDC WONDER Database, accessed February 1, 2025; JACC Cardiovascular Statistics in the United States, 2026.

The 2023 CHD mortality figures confirmed by the AHA’s 2026 Statistics Update carry genuinely mixed messages that deserve careful interpretation. The drop from 371,506 deaths in 2022 to 349,470 in 2023 — a reduction of roughly 22,000 lives — is meaningful and reflects the broader post-COVID-19 rebound in overall life expectancy now filtering through cardiovascular outcomes data. But 349,470 deaths from a single disease in a single year is still a staggering toll — equivalent to the entire population of a major American city — and CHD’s 38.2% share of all CVD deaths means it remains the dominant cardiovascular killer by a wide margin over stroke (17.8%), heart failure (9.8%), and hypertensive diseases (14.5%). The age-adjusted CVD death rate of 218.3 per 100,000 in 2023 is an improvement over 224.3 in 2022, and the long-term story of a ~50% reduction in CAD mortality between 2000 and 2020 is genuinely one of modern medicine’s significant achievements. However, the fact that 1 in 6 CVD deaths in 2023 was among adults younger than 65 signals a deeply troubling premature mortality burden driven by rising rates of obesity, diabetes, and hypertension appearing at earlier ages than in any previous generation.

Coronary Heart Disease by Race and Ethnicity in the US 2026

The racial and ethnic disparities embedded in coronary heart disease statistics represent one of the most persistent, urgent, and ethically significant findings across all major national cardiovascular surveillance reports.

Race/Ethnicity% of All CVD Deaths (2021)CVD PrevalenceKey Disparity
American Indian or Alaska Native15.5%High CHD burdenGeographic + access barriers
Asian adults18.6%Lowest CVD overall; but CAD rising fastRate jumped from 2.8% to 3.8%
Black (Non-Hispanic) adults22.6%~59% any CVD (2017–2020)Highest share of heart disease deaths
Native Hawaiian/Pacific Islander18.3%Significant burdenOften underrepresented in data
White (Non-Hispanic) adults18.0%Highest CAD-specific rate (5.4%)CAD most prevalent in this group
Hispanic adults11.9%Lower overall mortalityHispanic paradox — lower mortality despite risk
All groups combined17.4%~50% any CVD (2021–2023)National average
Black men — statin use (prior ASCVD)Below White peersaPR: 0.81 vs White menSignificant treatment gap
Hispanic women — statin useLowest of any groupaPR: 0.57 vs White womenCritical prescription inequity
High-risk Black/Hispanic (no prior ASCVD) — statin useBlack: 23.8%, Hispanic: 23.9%vs White: 37.6%60% lower treatment rate

Source: CDC Heart Disease Facts, cdc.gov, updated October 2024; AHA 2026 Heart Disease and Stroke Statistics Update — Palaniappan LP et al., Circulation, January 21, 2026; JACC Cardiovascular Statistics in the United States, 2026 — Wadhera RK et al., J Am Coll Cardiol., January 12, 2026.

The racial and ethnic data embedded in US coronary heart disease statistics 2026 reveals a healthcare system that is not serving all Americans equally — and has not for generations. Non-Hispanic Black adults carry the heaviest proportional burden of CVD deaths at 22.6% of all cardiovascular deaths in 2021, alongside a staggering ~59% CVD prevalence in NHANES 2017–2020 data, meaning more than half of all Black American adults were already living with some form of cardiovascular disease during that period. JACC Stats 2026 adds an equally troubling treatment gap dimension: non-Hispanic Black men are significantly less likely than White men to be on statin therapy following a cardiovascular event (adjusted prevalence ratio 0.81), and Mexican American and non-Mexican Hispanic women have some of the lowest statin adherence rates of any group — receiving guideline-recommended preventive therapy at barely half the rate of White women. These are not gaps in biological predisposition — they are gaps in access, prescribing patterns, trust, and structural equity within the US healthcare system. The alarming rise in Asian adults’ CAD rate from 2.8% to 3.8% — a nearly 36% relative jump in just a few years — combined with projections showing diabetes prevalence rising to 26.8% of US adults by 2050, predominantly in minority subgroups, means that today’s disparities will compound dramatically unless targeted action is taken now.

Heart Attack Statistics in the US 2026

Heart attacks (myocardial infarctions) are the most acute, dangerous, and visible manifestation of coronary heart disease in the US, and the frequency with which they strike Americans remains one of the most jarring statistics in the entire cardiovascular surveillance dataset.

Heart Attack MetricLatest Verified Data
Annual heart attacks in the USApproximately 805,000 per year
First heart attacks per year605,000
Recurrent heart attacks per year200,000
Heart attack frequencyOne every 40 seconds in the US
Silent heart attacksAbout 1 in 5 (20%) are silent
Average age of first MI — men65.6 years
Average age of first MI — women72.0 years
AMI hospitalizations (2004)3 per 1,000 adults
AMI hospitalizations (2010)2.3 per 1,000 adults (then stable through 2018)
AMI hospitalizations — younger adults (post-2019)Rising — alarming reversal
Out-of-hospital cardiac arrest survival (2024)Only 10.5% survived to hospital discharge
Bystander CPR rate — out-of-hospital CA (2024)Only 42% received bystander CPR
Public AED use — out-of-hospital CA (2024)Only 13%
Out-of-hospital cardiac arrests occurring at home71% occur at home (2023 data)
CHD death rate decline (2012–2022)16.9% age-adjusted — real progress, now stalling
Women after MIMore likely to die than men

Source: CDC Heart Disease Facts, cdc.gov, October 2024; AHA 2026 Heart Disease and Stroke Statistics Update — Palaniappan LP et al., Circulation, January 21, 2026; JACC Cardiovascular Statistics in the United States, 2026 — Wadhera RK et al., J Am Coll Cardiol., January 12, 2026; AHA 2026 Top Takeaways document, professional.heart.org.

The sheer volume of heart attacks in the United States805,000 per year, one every 40 seconds — demands to be taken seriously both as a public health emergency and as a deeply personal risk for millions of American families. The breakdown between 605,000 first heart attacks and 200,000 recurrent events highlights two entirely distinct prevention battles: stopping a first MI from ever occurring through primary prevention and lifestyle intervention, and ensuring that the people who have already survived one receive the optimal secondary prevention therapies that keep a second event from happening. The data confirming that only 1 in 2 CHD patients receives optimal medical therapy maps directly onto that 200,000 annual recurrent heart attack figure — representing preventable events in diagnosed patients who are not receiving guideline care. The emergency response data from 2024 adds another dimension to the tragedy: with only 42% bystander CPR rates and only 10.5% survival to hospital discharge for out-of-hospital cardiac arrests, the gap between what emergency response science makes possible and what actually happens in American communities is enormous and entirely closable with training and public investment. The rise in AMI hospitalizations among younger American adults since 2019 — at a time when this metric had been stable for nearly a decade — confirms that obesity and diabetes are compressing the disease timeline into younger and younger cohorts.

Coronary Heart Disease Risk Factors Statistics in the US 2026

The major modifiable risk factors for coronary heart disease are well established, evidence-based, and largely controllable — yet the data confirms that the United States is failing to control them at the population level.

Risk FactorLatest US Data (2021–2023 unless noted)Trend
Hypertension — adults125.9 million — 47.3% of all US adultsUp from 122.4 million (46.7%) in 2017–2020
Blood pressure control rate48.3% in 2017–2020Down from 54.1% in 2013–2014
Diagnosed diabetes29.5 million US adultsUp from 29.3 million in 2017–2020
Prediabetes96 million US adultsVastly underdiagnosed and undertreated
Undiagnosed diabetes9.6 millionUnknown to the individuals affected
Glycemic control (treated Type 2 diabetes)Only 43.5% achieving controlDeclining from prior years
Obesity (BMI ≥30) among adults40.1%Up from 34.5% in 2011–2012
Mean adult BMI (2021–2023)29.6 kg/m²Up from 28.6 kg/m² in 2011–2012
Obesity in youth age 2–1928.1%Up from 25.4% in 2017–2020
CKM syndrome — any level (US adults)~90% of all US adultsNew AHA 2026 chapter — alarming finding
Early CKM risk (young/middle-aged adults)Over 80% already show early CKM riskFoundational driver of future CHD
Adults with ZERO CVD risk factorsOnly 36.4%Majority carry at least 1 major risk factor
Type 2 diabetes mortality (2023)54.0 deaths per 100,000Up from 30.4 per 100,000 in 2009
Physical activity guidelines met (2022)Only 25.3% met aerobic + strength guidelinesMost adults remain insufficiently active
Hypertension projected prevalence by 205061% of US adultsAHA 2026 modeling
Diabetes projected prevalence by 205026.8% of US adultsSharp increase from current levels

Source: AHA 2026 Heart Disease and Stroke Statistics Update — Palaniappan LP et al., Circulation, January 21, 2026; JACC Cardiovascular Statistics in the United States, 2026 — Wadhera RK et al., J Am Coll Cardiol., January 12, 2026; CDC NCHS Data Brief No. 540, September 2025 (Prevalence of Cardiovascular Disease Risk Factors in Adults: United States, August 2021–August 2023).

The risk factor data for coronary heart disease in the US 2026 reads less like a progress report and more like a slow-motion emergency that has been building for years. The finding that only 36.4% of American adults carry zero major CVD risk factors means that roughly two-thirds of the entire adult population — well over 150 million people — already have one or more conditions actively driving them toward a future heart attack or CHD diagnosis. Hypertension, now affecting 125.9 million Americans — 47.3% of all adults — has seen its control rate actually decline from 54.1% in 2013–2014 to 48.3% by 2017–2020, a regression that occurred despite 15 years of available, affordable, and highly effective antihypertensive medications. The diabetes landscape is no less alarming: 29.5 million with diagnosed diabetes, 96 million with prediabetes, and only 43.5% of those being treated achieving adequate glycemic control — three compounding failures that together place an enormous additional CHD burden on the country year after year. The entirely new chapter on cardiovascular-kidney-metabolic (CKM) syndrome in the AHA 2026 Statistics Update — finding that 90% of US adults already have some level of CKM syndrome — offers perhaps the clearest lens of all on the scale of the underlying risk crisis that will drive coronary heart disease in America for decades to come unless prevention becomes the true national priority it has never yet fully been.

Coronary Heart Disease Economic Burden in the US 2026

The financial cost of coronary heart disease in the United States is enormous by any measure — affecting individual patients, employer productivity, insurance systems, and government healthcare programs alike.

Economic / Healthcare Cost MetricVerified Data
Total CVD cost — direct + indirect (2021–2022)$414.7 billion estimated total
Direct CVD healthcare services + medications cost$168+ billion annually
Annual CVD cost estimate — NHLBI MEPS (2019–2020)Approximately $422.3 billion
CVD inpatient hospital costs (2019–2020)$110.3 billion direct
Direct CVD costs increase (1996–97 to 2019–20)From $103.5 billion to $254.3 billion
Physician office visits for coronary atherosclerosis/ischemic HD13.0 million per year
ER visits with CAD/ischemic HD on record6.5% of all ER visits
Physician office visits with CAD history6.9% of all physician office visits
Projected CVD risk factor cost increase by 2050Expected to triple vs 2020 baseline
Projected hypertension prevalence by 205061% — driving massive future cost increase
AHA research investment since 1949$6.1 billion+ in cardiovascular research
CVD vs other causes — relative mortality costKills more than cancer + accidents combined annually

Source: AHA 2026 Heart Disease and Stroke Statistics Update — Palaniappan LP et al., Circulation, January 21, 2026; AHA 2026 At-a-Glance Fact Sheet, professional.heart.org, January 2026; CDC Heart Disease Facts, cdc.gov, October 2024; NHLBI MEPS tabulation as cited in AHA 2025 and 2026 Statistical Summary Tables; CDC NCHS FastStats — Heart Disease, cdc.gov/nchs/fastats.

The $414.7 billion total annual cost of cardiovascular disease in the United States — encompassing direct healthcare spending and lost productivity — makes CHD not just a health crisis but one of the most significant drivers of economic drag across the entire national economy. The near-tripling of direct CVD costs from $103.5 billion in 1996–97 to $254.3 billion by 2019–20 demonstrates how two decades of modest mortality improvements have been more than offset by a growing burden of chronic illness requiring sustained medication, repeat hospitalizations, revascularization procedures, and long-term cardiac rehabilitation. The 13 million physician office visits per year for coronary atherosclerosis and ischemic heart disease alone — alongside the fact that 6.9% of all physician office visits carry a CAD history on the medical record — illustrates the enormous ongoing demand this single disease places on primary care and specialist infrastructure alike. Looking forward, with hypertension projected to reach 61% of US adults and diabetes projected to reach 26.8% by 2050, the cost trajectory for coronary heart disease in America is unmistakably upward unless prevention and control of these upstream risk factors become the true centerpiece of national health investment.

Coronary Heart Disease Treatment and Care Gaps in the US 2026

The distance between what evidence-based medicine can deliver for CHD patients and what they actually receive defines one of the most correctable failures in American healthcare — with profound implications for preventable death and disability.

Treatment / Care Quality MetricLatest Verified Data
CHD patients receiving optimal medical therapyOnly 1 in 2 (50%) — JACC Cardiovascular Statistics 2026
Statin use — adults with ASCVD (2009–2010)55.7% — suboptimal baseline
Statin use — adults with ASCVD (2017–2020)60.8% — modest improvement, still deeply inadequate
Statin use — high-risk adults (10-yr ASCVD risk ≥7.5%, age 40–75)Only 19.1% on therapy (2017–2018)
Statin use — adults with diabetes, age 40–75Only 51.9% on therapy (2017–2018)
Statin use — high-risk Black adults (no prior ASCVD)23.8% vs 37.6% for White adults
Statin use — high-risk Hispanic adults (no prior ASCVD)23.9% vs 37.6% for White adults
Blood pressure control rate (2017–2020)48.3% — below 2013–2014 level of 54.1%
Type 2 diabetes glycemic controlOnly 43.5% of treated adults in control (2021–2023)
Eligible patients receiving bariatric surgeryOnly 1% of eligible individuals
Eligible patients receiving obesity medication (2010–2021)Only 1.6%
GLP-1 receptor agonist ever-use (as of November 2025)Only ~18% of Americans
Out-of-hospital cardiac arrest bystander CPR rate (2024)Only 42%
Out-of-hospital cardiac arrest public AED use (2024)Only 13%
Adults meeting physical activity guidelines (2022)Only 25.3% met both aerobic + strength guidelines

Source: JACC Cardiovascular Statistics in the United States, 2026 — Wadhera RK et al., J Am Coll Cardiol., January 12, 2026 (doi: 10.1016/j.jacc.2025.12.027); AHA 2026 Heart Disease and Stroke Statistics Update — Palaniappan LP et al., Circulation, January 21, 2026; AHA 2026 Top Takeaways, professional.heart.org, January 2026; CDC Heart Disease Facts, cdc.gov, October 2024.

The coronary heart disease treatment gap data for the US in 2026 is arguably the most actionable body of statistics in this entire article — because every underperformance data point it reveals represents lives that could be saved today, without waiting for new scientific breakthroughs or drug discoveries. The anchor finding from JACC Cardiovascular Statistics 2026 that only 1 in 2 Americans with CHD receives optimal medical therapy is not an outlier finding — it is drawn from nationally representative NHANES surveys and means that millions of diagnosed CHD patients are not receiving the combination of statins, antihypertensives, antiplatelet agents, and lifestyle interventions that current guidelines unambiguously recommend. The statin data is particularly striking: even among adults aged 40–75 with a 10-year ASCVD risk of 7.5% or higher — a group for whom statin therapy carries a Class I guideline recommendation — only 19.1% are actually taking the drug. The racial and ethnic prescribing gap compounds this failure: high-risk Black and Hispanic adults are receiving statin therapy at roughly 60% of the rate of comparable White adults, directly contributing to the mortality disparities documented elsewhere in the data. The arrival of GLP-1 receptor agonists with demonstrated cardiovascular benefit in high-risk populations, currently used by only ~18% of Americans for any indication as of November 2025, represents perhaps the most significant underutilized opportunity in modern cardiovascular prevention — one that the healthcare system must urgently and equitably scale.

Disclaimer: The data reports published on The Global Files are sourced from publicly available materials considered reliable. While efforts are made to ensure accuracy, no guarantees are provided regarding completeness or reliability. The Global Files is not liable for any errors, omissions, or damages resulting from the use of these reports.